A dangerous immune response —

Weight problems and obese are among the many greatest well being challenges of the twenty first century, in line with the World Well being Group (WHO). Nearly 60 % of Germans are thought-about obese, whereas 25 % are overweight. Furthermore, being obese typically triggers extreme secondary ailments corresponding to diabetes, arteriosclerosis, or coronary heart assaults.

Immunological processes decide the course of this illness. As a part of a brand new research, a gaggle of LMU researchers led by Dr. Susanne Stutte and Professor Barbara Walzog has proven {that a} high-caloric weight-reduction plan, even for a interval of solely three weeks, has drastic results on the immune system.

“A selected type of immune cells referred to as plasmacytoid dendritic cells (pDCs) begins to build up within the visceral adipose tissue,” explains Stutte. This adipose tissue is positioned contained in the stomach and surrounds inside organs. With excessive caloric weight-reduction plan, small clusters of immune cells type tertiary lymphoid buildings inside this fats, leading to deadly immune responses.

“Now, these pDCs in visceral fats are in a continuing state of alarm and launch type-I interferon,” explains Walzog. This interferon normally mediates the management of infections, however right here it triggers the metabolic syndrome: the metabolism derails and inflammatory markers rise. When the migration of pDCs into the fats is blocked, weight acquire is diminished and the metabolic situation improves significantly.

The outcomes of this research, which was carried out in collaboration with Harvard Medical College in Boston, might now contribute to the event of latest approaches towards a therapeutic intervention of the metabolic syndrome.

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