Even with statins, high triglycerides may increase risk of second stroke —

Stroke can have many causes. An atherothrombotic stroke is attributable to a clot that varieties from plaques that construct up inside blood vessels within the mind. A brand new examine means that individuals who have this sort of stroke who even have increased ranges of triglycerides, a sort of fats, of their blood might have the next danger of getting one other stroke or different cardiovascular issues one yr later, in comparison with individuals who had a stroke however have decrease triglyceride ranges. The analysis is printed within the March 16, 2022, on-line concern of Neurology®, the medical journal of the American Academy of Neurology. The examine discovered an affiliation even when folks had been taking statin medication meant to decrease triglycerides and shield towards coronary heart assault and stroke.

Elevated triglyceride ranges are thought to contribute to hardening of the arteries and elevated danger of coronary heart assault, coronary heart illness and stroke.

“Our examine means that for individuals who had atherothrombotic stroke, having elevated ranges of triglycerides of their blood is a danger issue for having one other stroke or different cardiovascular issues sooner or later, and we discovered that to be true even when the individual is on statin remedy,” mentioned examine writer Takao Hoshino, MD, of the Tokyo Girls’s Medical College in Japan. “The excellent news is that statin medicines are only one remedy for top triglycerides — weight-reduction plan and train will also be efficient methods to cut back the degrees in your blood at little or no price.”

The examine checked out 870 individuals who had a stroke or transient ischemic assault. Their common age was 70. Of these, 217, or 25%, had elevated triglyceride ranges, outlined as fasting triglycerides ranges 150 milligrams per deciliter or increased.

Researchers adopted up with the members one yr later to search out out if there was an affiliation between excessive triglyceride ranges and having one other stroke, acute coronary syndrome, which is any situation attributable to a sudden discount of blood stream to the guts, or dying on account of vascular causes.

After adjusting for elements like ldl cholesterol degree and statin use, researchers discovered that individuals who had excessive triglyceride ranges had a 21% larger danger of dying, stroke or coronary heart situation one yr, in comparison with 10% larger danger for these with decrease ranges.

When researchers seemed particularly at individuals who had one other stroke after an atherothrombotic stroke, they discovered that 14 out of 114 folks with regular triglyceride ranges, or 12%, had one throughout the examine, in comparison with 33 out of 217 folks, or 16%, of these with elevated ranges.

For acute coronary syndrome, one out of 114 folks, or 0.9%, with regular triglyceride ranges developed the guts situation one yr after an atherothrombotic stroke, in comparison with 5 out of 60, or 8%, of these with elevated ranges.

Hoshino notes the examine didn’t discover an affiliation between increased triglyceride ranges and future cardiovascular issues in individuals who had a special sort of stroke known as cardioembolic stroke.

“Extra analysis is required, however for individuals who have had an atherothrombotic stroke, triglyceride ranges might emerge as a key goal for stopping future strokes and different cardiovascular issues,” Hoshino mentioned. “Statin remedy continues to be an efficient therapy for folks with excessive triglyceride ranges, however our examine highlights how vital it’s to take a look at all of the instruments an individual can use to decrease their triglycerides, together with weight-reduction plan modifications, train and taking omega-3 fatty acids.”

The examine doesn’t show that decreasing excessive triglyceride ranges will stop folks with atherothrombotic strokes from having cardiovascular issues later; it solely exhibits an affiliation.

A limitation of the examine is that researchers thought of solely the members’ fasting ranges of triglycerides.

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Supplies supplied by American Academy of Neurology. Word: Content material could also be edited for type and size.