Losartan is not effective in reducing COVID-19 lung injuries, researchers find —


A examine revealed in JAMA Community Open, from the College of Minnesota, discovered {that a} widespread blood stress remedy — losartan — just isn’t efficient in decreasing lung damage in sufferers with COVID-19.

This drug was investigated based mostly on early reviews suggesting profit in preclinical fashions of the 2003 SARS virus, an in depth member of the family to the present SARS-CoV-2 virus. This examine was carried out throughout 12 U.S. tutorial analysis establishments.

The U of M Medical College and College of Public Well being analysis workforce sought to find out if a standard blood stress remedy would possibly lower lung damage in sufferers admitted to the hospital with COVID-19. Their outcomes discovered that losartan remedy didn’t cut back lung damage in sufferers admitted with COVID-19, and had no impact on mortality.

The researchers additionally discovered that critically-ill sufferers handled with losartan wanted further, short-term blood stress help — although this didn’t result in worse outcomes general.

“Although this explicit drug was not efficient for the remedy of COVID-19, repurposing cheap and comparatively protected drugs stays an essential strategy to comprise healthcare prices,” stated Michael Puskarich, MD, an affiliate professor in emergency medication on the U of M Medical College and co-author of this examine.

“Discovering efficient remedies for COVID-19 that may be broadly used throughout each the developed and growing world stays an essential ongoing space of investigation,” Puskarich stated, who can also be an emergency doctor at Hennepin Healthcare.

This examine was funded by the Invoice and Melinda Gates Basis. The researchers notice that extra research of protein and mobile signaling from ALPS-COVID trial members are ongoing.

“We hope that future examine findings of those proteins might present insights into why the physique responds the way in which it does to COVID-19,” stated Christopher Tignanelli, MD, MS, FACS, FAMIA, an assistant professor in surgical procedure on the U of M Medical College and co-author on this examine. “Critically, this can assist us perceive why some folks develop extreme illness following COVID-19 an infection and others are asymptomatic.”

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Supplies offered by College of Minnesota Medical College. Authentic written by Kat Dodge. Observe: Content material could also be edited for fashion and size.